Noonan occurs between 1 in 1000 to 2,500 people. Most commonly caused by the mutation in the gene PTPN11 which SHP-2 protein that plays a role in transduction signaling including signaling RAS-mitrogen activated protein kinase. This mutation within the protein can cause a number of mental and physical abnormalities while still having a normal karyotype. This disorder can be both hereditary and appear out nowhere. So detecting this disease becomes a little tricky when trying to figure out who in the family has it. However if it is found to be that one parent has the trait then the child has a fifty percent chance of getting this disorder. While there are many treatments for the disorder there is no way to actually stop the disorder.